Protein domains are distinct functional and/or structural units within a protein [1]. By investigating the domains of a gene can help researchers have a deeper understanding of the function of the gene. Domains listed below are generated by Interpro and SMART, which are databases used for identifying and visualizing protein domains based on amino acid sequence.
OPA1 PROTEIN DOMAIN
Human has 1015 amino acids within the OPA1 protein. The dynamin-type guanine nucleotide binding domain and the dynamin-like GTPase C-terminal were highlighted with blue and black.
Protein domains for orthologs were obtained by blasting FASTA sequences. There are minor differences between the model organisms. Some has similar lengths, some has sites at similar range. However, the GTPase C-terminal was not identified within A. Thaliana.
dISCUSSION
There are two conserved domains in the OPA1 protein, the guanine nucleotide-biding domain and the GTPase OPA1 C-terminal. The two domains are responsible for different protein functions. And based on the result, the OPA1 protein is well conserved across the animal and plant kingdoms.
This web page was produced as an assignment for Genetics 564, a capstone course at UW-Madison. Dianna Xie | [email protected] | Last updated 05/09/2024